Does taking diphenhydramine increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. Results from one study did not show an increased chance of miscarriage with the use of antihistamines, including diphenhydramine, in early pregnancy.
Does taking diphenhydramine increase the chance of birth defects?
Birth defects can happen in any pregnancy for different reasons. Out of all babies born each year, about 3 out of 100 (3%) will have a birth defect. We look at research studies to try to understand if an exposure, like diphenhydramine, might increase the chance of birth defects in a pregnancy.
A few studies have suggested a higher chance for birth defects when diphenhydramine is used during the first trimester. However, these studies do not all agree, and no consistent pattern of birth defects has been noted. There are also several studies that reported no increased chance of birth defects with the use of diphenhydramine in early pregnancy.
Does taking diphenhydramine in pregnancy increase the chance of other pregnancy-related problems?
Occasional use of diphenhydramine at recommended doses is not expected to increase the chance of other pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
There are reports of other issues, including uterine contractions and, very rarely, fetal death with the use of diphenhydramine in the third trimester. However, these reports usually involve using more of the medication than is recommended or using it for longer than the recommended time.
Can I take diphenhydramine with a benzodiazepine?
There is a single human report and some animal data that has suggested that the combination of a medication called temazepam (a benzodiazepine) and diphenhydramine might increase the chance of stillbirth or infant death shortly after birth. It has been recommended that these two medications not be used together during pregnancy. People who take temazepam should talk with their healthcare provider before taking diphenhydramine during their pregnancy. MotherToBaby has a fact sheet on temazepam here.
I need to take diphenhydramine throughout my entire pregnancy. Will it cause withdrawal symptoms in my baby after birth?
The use of diphenhydramine during pregnancy can cause temporary symptoms in newborns soon after birth. These symptoms are sometimes referred to as withdrawal. There are a few reports of withdrawal symptoms (tremors and diarrhea) in infants who were exposed to diphenhydramine daily throughout pregnancy. Not all babies exposed to diphenhydramine will have these symptoms. It is important that your healthcare providers know you are taking diphenhydramine so that if symptoms occur your baby can get the care that is best for them.
Does taking diphenhydramine in pregnancy affect future behavior or learning for the child?
It is not known if diphenhydramine increases the chance for behavior or learning issues.
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