Does taking vitamin D increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. There is mixed information about low levels of vitamin D (blood levels of vitamin D below 50 nmol/L) and a possible increased chance of miscarriage. In 1 study of over 1,600 people that looked at low levels of vitamin D during pregnancy, an increased chance of miscarriage was reported. However, another study among 5,000 people did not find an increased chance of miscarriage with low levels of vitamin D during pregnancy. Another study found that people who had multiple miscarriages had lower blood concentrations of vitamin D compared to those who had not had multiple miscarriages. Because there can be many causes of miscarriage, it is hard to know if a supplement, an underlying medical condition, or other factors are the cause of a miscarriage.
Does taking vitamin D increase the chance of birth defects?
Birth defects can happen in any pregnancy for different reasons. Out of all babies born each year, about 3 out of 100 (3%) will have a birth defect. It is not known if high or low levels of vitamin D might affect the chance of birth defects.
In 27 case reports of infants exposed to high levels of vitamin D (blood levels of vitamin D above 125 nmol/L) during pregnancy, there was no reported increase in the chance of birth defects.
Data from two studies with 192 people suggest a link between neural tube defects (birth defects where the spinal cord or brain did not form correctly) and low levels of vitamin D. This is not enough data to know if low levels of vitamin D increase the chance of birth defects.
Does taking vitamin D in pregnancy increase the chance of other pregnancy-related problems?
Limited information suggests taking vitamin D within the RDA is not expected to increase the chance of pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
High levels of vitamin D (blood levels of vitamin D above 125 nmol/L) have not been linked to an increased chance of pregnancy-related problems. There are case reports of an infant having hypercalcemia (high levels of calcium) after being exposed to high levels of vitamin D during pregnancy. However, no increase in hypercalcemia or hypercalciuria (high levels of calcium in the urine) was reported in a clinical trial of vitamin D supplementation of 2000 IU vs 4000 IU during pregnancy.
Having low levels of vitamin D in pregnancy might increase the chance of low birth weight, low infant calcium levels (hypocalcemia), or preeclampsia (high blood pressure and problems with organs, such as the kidneys), which can lead to seizures (called eclampsia). Low levels of vitamin D have been associated with preterm birth with non-white but not white women who are pregnant.
Does taking vitamin D in pregnancy affect future behavior or learning for the child?
No behavioral or learning differences were reported in 27 case reports of children exposed to high levels of vitamin D (blood levels of vitamin D above 125 nmol/L) during pregnancy,
Some studies have suggested that low levels of vitamin D in pregnancy might increase the chance for the child to have attention deficit hyperactive disorder (ADHD), lower language skills, or autism spectrum disorder. However, many factors are involved when a person develops one or more of these conditions. That makes it hard to study these outcomes and most of these studies did not look at other factors such as underlying medical conditions, family history, medications used, or other exposures. Overall, there is not enough evidence to say that low levels of vitamin D in pregnancy increase the chance of ADHD, lower language skills, or autism spectrum disorder.
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