Does taking loratadine increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. A study of 161 women taking loratadine during the first trimester of pregnancy did not show an increased chance of miscarriage.
Does taking loratadine increase the chance of birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Taking loratadine is not expected to increase the chance of birth defects above the background risk. One early study raised concern about a possible link between loratadine use in pregnancy and hypospadias (a birth defect where the opening of the penis is shifted toward the underside rather than the tip). However, after later studies did not find the same link, the researchers decided that the cases of hypospadias in their original study were most likely due to chance or other factors instead of exposure to loratadine.
Other studies of loratadine use during pregnancy have not found an increased chance of any kind of birth defect, including hypospadias. Also, studies have not found that infants with hypospadias were more often exposed to loratadine during pregnancy than infants without hypospadias.
Does taking loratadine in pregnancy increase the chance of other pregnancy-related problems?
Loratadine is not expected to increase the chance of pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
Does taking loratadine in pregnancy affect future behavior or learning for the child?
Studies have not been done to see if loratadine can cause behavior or learning issues for the child.
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