Does taking duloxetine increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. It is not known if taking duloxetine can increase the chance of miscarriage. Two studies reported that taking duloxetine could slightly increase the chance of miscarriage. Other studies have not reported an increased chance. As there can be many causes of miscarriage, including depression itself, it is hard to know if a medication, underlying condition, or other factors are the cause of a miscarriage.
Does taking duloxetine increase the chance of birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Taking duloxetine in pregnancy is not expected to increase the chance of birth defects above the background risk.
Does taking duloxetine in pregnancy increase the chance of other pregnancy-related problems?
Some studies suggest that taking duloxetine throughout pregnancy might increase the chance for pregnancy complications such as high blood pressure disorders and heavy bleeding after birth. However, research has also shown that when depression is left untreated during pregnancy, there could be an increased chance for pregnancy complications. This makes it hard to know if it is the medication, depression, or other factors that can increase the chance for these problems.
I need to take duloxetine throughout my entire pregnancy. Will it cause withdrawal symptoms in my baby after birth?
The use of duloxetine during pregnancy can cause temporary symptoms in newborns soon after birth. These symptoms are sometimes referred to as withdrawal. Symptoms might include breathing problems, jitteriness / tremors, more or less muscle tone than usual, irritability, problems sleeping, and trouble eating or regulating their body temperature. Most of the time the symptoms are mild and go away on their own, usually within a few weeks. In rare cases, some babies might need to stay in a special care nursery for a few days until these symptoms go away. Not all babies exposed to duloxetine will have symptoms. It is important that your healthcare providers know you are taking duloxetine so that if symptoms occur your baby can get the care that is best for them.
Does taking duloxetine in pregnancy affect future behavior or learning for the child?
Studies have not been done to see if duloxetine can cause behavior or learning issues for the child.
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