Does taking promethazine increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many reasons. One small study did not report an increased chance of miscarriage in women taking promethazine.
Does taking promethazine increase the chance of birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Use of promethazine during pregnancy is not expected to increase the chance of birth defects above the background risk.
Does taking promethazine in pregnancy increase the chance of other pregnancy-related problems?
It is not known if promethazine can cause other pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
Using promethazine late in pregnancy might increase the chance of slowed breathing (respiratory depression) in newborns. It is important that your healthcare providers know you are taking promethazine so that if respiratory depression happens your baby can get the care that is best for them.
Does taking promethazine in pregnancy affect future behavior or learning for the child?
It is not known if promethazine increases the chance for behavior or learning issues.
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