Does taking doxylamine succinate-pyridoxine hydrochloride increase the chance of miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. Based on the studies reviewed, doxylamine succinate-pyridoxine hydrochloride does not increase the chance of miscarriage.
Does taking doxylamine succinate-pyridoxine hydrochloride increase the chance of birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Studies totaling hundreds of thousands of exposed pregnancies have not found that using doxylamine succinate-pyridoxine hydrochloride during pregnancy increases the chance of birth defects. The combination of doxylamine succinate and pyridoxine hydrochloride has been recommended as a first-line treatment for NVP by the American Congress of Obstetricians and Gynecologists (ACOG) and by several medical organizations in Canada for almost 20 years.
Does taking doxylamine succinate-pyridoxine hydrochloride in pregnancy increase the chance of other pregnancy related problems?
Studies have found that taking doxylamine succinate-pyridoxine hydrochloride does not increase the chance for pregnancy-related problems such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
Does taking doxylamine succinate-pyridoxine hydrochloride in pregnancy affect future behavior or learning for the child?
Studies that have followed children from ages 2 to 7 years have not found a higher chance of behavior or learning problems in children whose were exposed to doxylamine succinate-pyridoxine hydrochloride during pregnancy.
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